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L-[S-methyl-11C]methionine - An example of radiosynthetic optimization. 2018
Verena Pichler, and
Chrysoula Vraka, and
Neydher Berroterán-Infante, and
Andreas Krcal, and
Harald Eidherr, and
Tatjana Traub-Weidinger, and
Marcus Hacker, and
Markus Mitterhauser, and
Wolfgang Wadsak
Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: verena.pichler@meduniwien.ac.at.
Radiosynthetic optimization is crucial in routine PET production but is often neglected in literature. Small changes in the radiochemical procedure can increase the yield significantly and reduce time fluctuation within the synthetic procedure enabling better planning and product release on time. Therefore, a highly reproducible production method for L-[S-methyl-11C]methionine is presented, which uses a fully automated GE TRACERlab FX C Pro synthesizer. Evolution of the synthetic procedure lead to a protocol with a nearly doubled absolute yield.
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