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Adjuvant and antitumor activities of synthetic-6-O-mycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine and 6-O-mycoloyl-N-acetylmuramyl-glycyl-D-isoglutamine were examined in comparison with those of 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine. Synthetic 6-O-mycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine was active as an adjuvant for the induction of delayed-type hypersensitivity to m-[4-(4'-arsono-phenylazo)-phenyl]-N-acetyl-L-tyrosine in guinea pigs and for cell-mediated cytotoxicity in allogeneic mice. 6-O-mycoloyl-N-acetylmuramyl-glycyl-D-isoglutamine was inactive as an adjuvant for the induction of delayed-type hypersensitivity in guinea pigs; however, it was active for cell-mediated cytotoxicity in allogeneic mice. 6-O-mycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine and 6-O-mycoloyl-N-acetylmuramyl-glycyl-D-isoglutamine were not pyrogenic in rabbits. The antitumor activity of these 6-O-mycoloyl-N-acetylmuramyldipeptides was examined preliminarily by using transplantable syngeneic mouse tumors.
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
January 1979,
Microbiology and immunology,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
December 1977,
Cellular immunology,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
November 1979,
Cancer research,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
June 1977,
Biken journal,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
September 1981,
Infection and immunity,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
January 1991,
Biomedical science,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
June 1981,
Chemical & pharmaceutical bulletin,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
January 1979,
Microbiology and immunology,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
August 1980,
Immunology,
M Uemiya, and
K Sugimura, and
T Kusama, and
I Saiki, and
M Yamawaki, and
I Azuma, and
Y Yamamura
March 1978,
Infection and immunity,
