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Inhibition of DNA synthesis by rubomycin (daunorubicin), carminomycin and doxorubicin in the spleen, liver, kidneys and heart was studied on mice. The antibiotics were administered intravenously in a dose of 0.3 LD50. The inhibition level was estimated by incorporation of 3H-thymidine. The time courses of DNA synthesis inhibition by daunorubicin, carminomycin and doxorubicin markedly differed, whereas the patterns of their inhibition curves for all the organs were close. The maximum inhibition of DNA synthesis by carminomycin was observed in 6 hours. After that period it gradually restored. Doxorubicin induced the maximum inhibition of DNA synthesis in 24-48 hours after its administration. Daunorubicin induced two maxima in inhibition of DNA synthesis i. e. in 6 and 48 hours. Definite correlation between the levels of DNA synthesis inhibition by the antibiotics and their toxic action was shown.
M I Reznikova, and
Iu V Dudnik
May 1984,
Biochimie,
M I Reznikova, and
Iu V Dudnik
August 2001,
Electrophoresis,
M I Reznikova, and
Iu V Dudnik
October 1986,
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology,
M I Reznikova, and
Iu V Dudnik
December 1976,
Antibiotiki,
M I Reznikova, and
Iu V Dudnik
June 1980,
Research communications in chemical pathology and pharmacology,
M I Reznikova, and
Iu V Dudnik
June 1991,
Cancer communications,
M I Reznikova, and
Iu V Dudnik
January 1978,
Antibiotiki,
M I Reznikova, and
Iu V Dudnik
February 1979,
Antibiotiki,
M I Reznikova, and
Iu V Dudnik
December 2001,
Biochemistry,
M I Reznikova, and
Iu V Dudnik
April 1987,
Biochemistry,
