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Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21. 1986

R G Hards, and S J Benkovic, and M L Van Keuren, and S L Graw, and H A Drabkin, and D Patterson

Using a series of human-hamster hybrid cell lines, a gene coding for glycinamide ribonucleotide transformylase was mapped to human chromosome 21. The availability of hybrids containing only portions of chromosome 21 allowed the gene to be assigned to the region between the q11.2 and the q22.2 bands, inclusive. Differentiation of human and hamster glycinamide ribonucleotide transformylase was accomplished via an immunoprecipitation assay that employed a polyclonal antibody raised against the human enzyme.

UI MeSH Term Description Entries
D007158 Immunologic Techniques Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies. Antibody Dissociation,Immunologic Technic,Immunologic Technics,Immunologic Technique,Immunological Technics,Immunological Techniques,Technic, Immunologic,Technics, Immunologic,Technique, Immunologic,Techniques, Immunologic,Antibody Dissociations,Dissociation, Antibody,Dissociations, Antibody,Immunological Technic,Immunological Technique,Technic, Immunological,Technics, Immunological,Technique, Immunological,Techniques, Immunological
D011687 Purines A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002904 Chromosomes, Human, 21-22 and Y The short, acrocentric human chromosomes, called group G in the human chromosome classification. This group consists of chromosome pairs 21 and 22 and the Y chromosome. Chromosomes G,Group G Chromosomes,Chromosomes, Human, 21 22,Chromosomes, Human, 21-22,Chromosome, Group G,Chromosomes, Group G,Group G Chromosome
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006822 Hybrid Cells Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION. Somatic Cell Hybrids,Cell Hybrid, Somatic,Cell Hybrids, Somatic,Cell, Hybrid,Cells, Hybrid,Hybrid Cell,Hybrid, Somatic Cell,Hybrids, Somatic Cell,Somatic Cell Hybrid
D000217 Acyltransferases Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3. Acyltransferase
D051026 Phosphoribosylglycinamide Formyltransferase An enzyme that catalyzes the transfer of a formyl group from N10-formyltetrahydrofolate to N1-(5-phospho-D-ribosyl)glycinamide to yield N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and tetrahydrofolate. It plays a role in the de novo purine biosynthetic pathway. 2-Amino-N-Ribosylacetamide 5'-Phosphate Transformylase,5'-Phosphoribosylglycinamide Transformylase,GAR Formyltransferase,GAR Transformylase,GARTFase,Glycinamide Ribonucleotide Transformylase,Glycinamideribotide Transformylase,2 Amino N Ribosylacetamide 5' Phosphate Transformylase,5' Phosphoribosylglycinamide Transformylase,5'-Phosphate Transformylase, 2-Amino-N-Ribosylacetamide,Formyltransferase, GAR,Formyltransferase, Phosphoribosylglycinamide,Ribonucleotide Transformylase, Glycinamide,Transformylase, 2-Amino-N-Ribosylacetamide 5'-Phosphate,Transformylase, 5'-Phosphoribosylglycinamide,Transformylase, GAR,Transformylase, Glycinamide Ribonucleotide,Transformylase, Glycinamideribotide
D019877 Hydroxymethyl and Formyl Transferases Enzymes that catalyze the transfer of hydroxymethyl or formyl groups. EC 2.1.2. Formyl Transferase,Formyltransferase,Hydroxymethyl Transferase,Hydroxymethyl and Formyl Transferase,Hydroxymethyltransferase,Transhydroxymethylase,Formyl Transferases,Formyltransferases,Hydroxymethyl Transferases,Hydroxymethyltransferases,Transformylase,Transformylases,Transhydroxymethylases,Transferase, Formyl,Transferase, Hydroxymethyl,Transferases, Formyl,Transferases, Hydroxymethyl

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