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Ninety-six juvenile onset type diabetics showed an increase in the frequency of HLA B8 and B15 and a decrease in frequency of HLA B7 antigens. Sixty-four maturity onset diabetics showed no disturbance in the frequency of these antigens. Fifty-four of the juvenile onset type diabetics, with an average duration of disease of 3.2 years were tested for the presence of islet cell antibodies (ICAs). Thirty-two percent were positive, the frequency decreasing from 70% in those patients tested within one year of diagnosis to 0.5% in those patients tested more than 5 years after diagnosis. No correlation was found between HLA type and the frequency of ICAs, but there was an increase in other autoantibodies in B15 positive patients. Preliminary absorption studies suggest a cross reactivity of ICAs and Coxsackie B4 virus.
E R Richens, and
J Quilley, and
M Hartog
August 1978,
The New England journal of medicine,
E R Richens, and
J Quilley, and
M Hartog
August 1977,
Deutsche medizinische Wochenschrift (1946),
E R Richens, and
J Quilley, and
M Hartog
April 1975,
Lancet (London, England),
E R Richens, and
J Quilley, and
M Hartog
May 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
E R Richens, and
J Quilley, and
M Hartog
December 1976,
Lancet (London, England),
E R Richens, and
J Quilley, and
M Hartog
March 1991,
JPMA. The Journal of the Pakistan Medical Association,
E R Richens, and
J Quilley, and
M Hartog
March 1980,
Medicina clinica,
E R Richens, and
J Quilley, and
M Hartog
January 1979,
Transactions of the Association of American Physicians,
E R Richens, and
J Quilley, and
M Hartog
September 1979,
Diabetologia,
E R Richens, and
J Quilley, and
M Hartog
April 1966,
Deutsche medizinische Wochenschrift (1946),
