Biomaterial Database

Cumulative human health risk analysis of trihalomethanes exposure in drinking water systems. 2022

Minashree Kumari, and S K Gupta

Department of Civil Engineering, Indian Institute of Technology Delhi, Huaz Khas-110016, India; Department of Environmental Science and Engineering, Indian Institute of Technology (ISM) Dhanbad-826004, Jharkhand, India. Electronic address: minashreekumari2501@gmail.com.

Chlorinated compounds on reaction with natural organic substances present in water leads to the formation of trihalomethanes (THMs), a major type of disinfection by-products (DBPs). Trihalomethanes (THMs) are the most widely investigated DBPs in drinking water systems because of their carcinogenic potential and subsequent adverse effects on human health. This study investigated the effect of gastro-intestinal absorption factor on human health risk assessment. Monitoring and analysis of water quality parameters and THMs levels in drinking water treatment plants revealed that the average values (306.5 μg/L) exceeded the recommended US EPA guidelines of 80 μg/L. Spearman rank (rho) correlation coefficient indicated that dissolved organic carbon is the major parameter influencing THMs formation. Monte Carlo simulations base risk assessment study was conducted for three different exposure pathways. The observed human health risk exposure effects due to THMs were below the recommended USEPA level (1.0 × 10-6) for both the drinking water treatment plants. Seasonal disparity on risk estimation analysis revealed higher risk in summer season followed by autumn which is principally due to high concentration of THMs in summers.

UI	MeSH Term	Description	Entries
D004202	Disinfectants	Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)	Biocide,Disinfectant,Biocides
D004203	Disinfection	Rendering pathogens harmless through the use of heat, antiseptics, antibacterial agents, etc.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014874	Water Pollutants, Chemical	Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.	Chemical Water Pollutants,Landfill Leachate,Leachate, Landfill,Pollutants, Chemical Water
D060766	Drinking Water	Water that is intended to be ingested.	Bottled Water,Potable Water,Water, Bottled,Water, Drinking,Water, Potable
D018508	Water Purification	Any of several processes in which undesirable impurities in water are removed or neutralized; for example, chlorination, filtration, primary treatment, ion exchange, and distillation. It includes treatment of WASTEWATER to provide potable and hygienic water in a controlled or closed environment as well as provision of public drinking water supplies.	Waste Water Purification,Waste Water Treatment,Wastewater Purification,Wastewater Treatment,Water Treatment,Purification, Waste Water,Purification, Wastewater,Purification, Water,Treatment, Waste Water,Treatment, Wastewater,Treatment, Water,Waste Water Purifications,Waste Water Treatments,Water Purification, Waste
D018570	Risk Assessment	The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)	Assessment, Risk,Benefit-Risk Assessment,Risk Analysis,Risk-Benefit Assessment,Health Risk Assessment,Risks and Benefits,Analysis, Risk,Assessment, Benefit-Risk,Assessment, Health Risk,Assessment, Risk-Benefit,Benefit Risk Assessment,Benefit-Risk Assessments,Benefits and Risks,Health Risk Assessments,Risk Analyses,Risk Assessment, Health,Risk Assessments,Risk Benefit Assessment,Risk-Benefit Assessments
D022882	Trihalomethanes	Methanes substituted with three halogen atoms, which may be the same or different.	Trihalomethane