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The molecule t-butylcyclohexane is one of the first examples of a branched alkyl group attached to a hydrocarbon ring shown to be capable of producing renal damage at the corticomedullary junction of male rats. A metabolic study of t-butylcyclohexane yielded the following urinary metabolites: trans-4-t-butylcyclohexanol, 2c-hydroxy-4t-t-butylcyclohexanol, 2-methyl-2-cyclohexylpropanoic acid, 2c-hydroxy-4c-t-butylcyclohexanol, 2-methyl-2-cyclohexyl-1,3-propanediol, 2t-hydroxy-4t-t-butylcyclohexanol, and cis -4-t-butylcyclohexanol. As with other hydrocarbons of similar molecular weight that induce nephropathy in male rats, preferential sites of oxidative metabolism were observed that could potentially be related to the pathogenesis.
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
July 1995,
Chemosphere,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
August 1987,
Toxicology letters,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
November 1988,
Toxicology and applied pharmacology,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
January 1990,
Journal of toxicology and environmental health,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
January 1989,
Journal of toxicology and environmental health,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
December 1987,
Toxicology and industrial health,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
January 1987,
Drug metabolism and disposition: the biological fate of chemicals,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
August 1989,
Toxicology and applied pharmacology,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
January 1993,
Drug metabolism and disposition: the biological fate of chemicals,
G M Henningsen, and
K O Yu, and
R A Salomon, and
M J Ferry, and
I Lopez, and
J Roberts, and
M P Servè
December 1983,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
