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This study was undertaken to assess the effect of ethanol ingestion on myocardial fatty acid metabolism in man. Nine individuals with informed consent and with a habitual ethanol consumption of approximately 40 g per day, but without any clinical signs of heart and metabolic disease, were examined after i.v. injection of omega-123I-heptadecanoic acid (IHA). Eight days later, these individuals were similarly examined after 2 h of continuous ingestion of a body weight dependent amount of ethanol, which was calculated to produce a blood level of 100 mg per 100 ml (1%). Then the subjects had been asked to reduce their ethanol consumption rigorously for 15 months. Subsequently after 2 weeks of abstinence a follow-up investigation without ethanol loading was carried out. The investigations were performed with an Anger scintillation camera in LAO-45 degrees projection. The measurement period was 40 min. Tracer accumulation and regional elimination half-times of IHA were analysed. In all patients, acute ethanol loading produced significant changes in pattern of accumulation and/or regional elimination half-times. Ethanol-induced alterations in segmental accumulation did not appear to be predictably correlated with changes in segmental elimination half-times. After rigorous reduction of ethanol consumption followed by 2 weeks of abstinence a normalization of the tracer uptake was observed; the distribution pattern was almost homogeneous. Also the regional elimination half-times became normal. The data demonstrate the significant effects of both chronic ethanol consumption and particularly acute ethanol loading on myocardial fatty acid metabolism and the reversibility of the effects.
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
January 2000,
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
November 1985,
Biochemical and biophysical research communications,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
November 1998,
Journal of molecular and cellular cardiology,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
May 1998,
General pharmacology,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
January 1998,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
December 1981,
The Journal of biological chemistry,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
August 1987,
Clinical science (London, England : 1979),
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
November 1965,
The Journal of laboratory and clinical medicine,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
February 1982,
Archives of biochemistry and biophysics,
A Höck, and
G Notohamiprodjo, and
G Spohr, and
K P Kaiser, and
C Freundlieb, and
K Vyska, and
W W Shreeve, and
H Schweitzer, and
L E Feinendegen
November 1998,
General pharmacology,
