-transparent.png){kind=logo}
The beta (1----3) glucan lentinan was tested for its capacity to increase the cytotoxic effect of murine peritoneal macrophages for human tumor cells in the presence of monoclonal antibodies (MAbs). Activity was maximum in macrophages obtained on day 5 following intraperitoneal injection of CBA mice with 2.5 mg of lentinan per kg body weight. Macrophages stimulated by lentinan were cytotoxic in conjunction with IgG1, IgG2a and IgG3 MAbs, but not with IgG2b, IgM, or IgA MAbs. The demonstration of a similar enhancing effect by lentinan on human macrophages might have implications for potentiating the tumoricidal effect of these macrophages in the presence of tumor antigen-specific MAbs.
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
April 1985,
Cancer research,
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
July 1990,
Neurosurgery,
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
January 1987,
Cancer immunology, immunotherapy : CII,
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
August 1986,
Journal of medical microbiology,
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
June 2009,
Neoplasia (New York, N.Y.),
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
November 1976,
Journal of immunology (Baltimore, Md. : 1950),
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
January 1985,
The Journal of experimental medicine,
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
December 2012,
Medical oncology (Northwood, London, England),
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
September 2003,
Haematologica,
D Herlyn, and
Y Kaneko, and
J Powe, and
T Aoki, and
H Koprowski
October 1982,
Infection and immunity,
