-transparent.png){kind=logo}
The pharmacokinetics of valproic acid (VPA) was investigated in six healthy volunteers. This was done by monitoring total and free (unbound) valproic acid levels in the serum, and the amount of one of its metabolites, VPA glucuronide, in the urine as a function of time, after a single dose administration of the parent drug. VPA half-life calculated from the urine data of the metabolite was shorter than the half-life calculated from the blood data. About 15 to 20 per cent of the administered oral dose of VPA was excreted in the urine as VPA glucuronide. The average free fraction of VPA obtained in this study, by using the EMIT technique, ranged from 1.5 to 11.5 per cent with a mean value of 4.9 per cent.
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
August 2013,
Journal of pharmacokinetics and pharmacodynamics,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
April 1982,
Epilepsia,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
March 2015,
Nutrition research (New York, N.Y.),
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
January 1985,
Arzneimittel-Forschung,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
January 1991,
International journal of clinical pharmacology research,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
July 1984,
Antimicrobial agents and chemotherapy,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
January 1995,
European journal of clinical pharmacology,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
January 1985,
Arzneimittel-Forschung,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
November 1980,
Acta pharmacologica et toxicologica,
M Bialer, and
Z Hussein, and
I Raz, and
O Abramsky, and
Y Herishanu, and
F Pachys
January 2008,
Arzneimittel-Forschung,
