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Several urea derivatives (monomethylurea, monoethylurea and diethylurea) give i.p. to mice 30 min before alloxan (75 mg/kg i.v.) were able to prevent the diabetogenic actions of alloxan. Protection by these agents correlated reasonably well with their capacity to react with (scavenge) the hydroxyl radical. Protection did not correlate with the capacity of the above agents to cause a transient hyperglycemia at the point of alloxan administration, which might have also been a potential means of protection. These data extend previously published data on the capacity of hydroxyl radical scavengers to protect against alloxan and add evidence to the concept that the hydroxyl radical, generated within the beta cells, is the species derived from alloxan responsible for the damage to beta cells.
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
November 1978,
European journal of pharmacology,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
January 1995,
Experientia,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
November 1986,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
October 1985,
Biochemical pharmacology,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
March 1947,
The Anatomical record,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
May 1976,
Biochemical pharmacology,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
March 1994,
Japanese journal of pharmacology,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
May 1962,
Archives of pathology,
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
November 1954,
Science (New York, N.Y.),
J Tibaldi, and
J Benjamin, and
F S Cabbat, and
R E Heikkila
March 1955,
Science (New York, N.Y.),
