Biomaterial Database

Effects of N-beta-phenylpropionyl-L-tyrosine and its derivatives on the excitability of an identifiable giant neuron of Achatina fulica férussac. 1982

H Takeuchi, and Y Ariyoshi

1. Previously the authors demonstrated the inhibitory effects of the two aromatic amino acid derivatives, N-beta-phenylpropionyl-L-Tyr (critical concentration (c.c.), 3 x 10(-7) - 10(-6) M) and N-beta-phenylpropionyl-L-Trp (c.c., 10(-6) M) on the excitability of an identifiable giant neuron, TAN (tonically autoactive neuron), of Achatina fulica Férussac. The effects of the derivatives of the two inhibitory compounds on the same neuron are examined in the present study. 2. N-beta-Cyclohexylpropionyl-L-Tyr (c.c., 3 x 10(-8) - 10(-7) M) and N-beta-cyclohexylpropionyl-L-Trp (c.c., 10(-6) M) had marked inhibitory effects, whereas N-beta-p-methyl-phenylpropionyl-L-Tyr had none. 3. N-gamma-Phenylbutyroyl-L-Tyr and N-phenylacetyl-L-Tyr, in which the chain length of the phenyl group is different, had no effect. 4. N-beta-Phenylpropionyl-N-methyl-L-Tyr, in which the imino group of the peptide bond is methylated, had no effect. 5. N-beta-Phenylpropionyl-L-Tyr (c.c., 3 x 10(-7) - 10(-6) M) and N-beta-phenylpropionyl-L-Tyr methylester (c.c. 1-3 x 10(-6) M) had marked inhibitory effects, suggesting that their carbonyl group acts as a proton acceptor. 6. N-beta-Phenylpropionyl-L-p-hydroxyphenylglycine, in which the chain length of the hydrogen binding group is shorter, had no effect. 7. N-beta-Phenylpropionyl-L-3,4-dihydroxy-Phe (c.c., 3 x 10(-6) M), N-beta-phenylpropionyl-L-3-nitro-Tyr (c.c., 3 x 10(-5) M) and N-beta-phenylpropionyl-L-p-amino-Phe (c.c., 3 x 10(-5) - 10(-4) M) had inhibitory effects, weaker than that of N-beta-phenylpropionyl-L-Tyr. N-beta-Phenylpropionyl-L-p-chloro-Phe and N-beta-phenylpropionyl-L-p-nitro-Phe showed the same effect only at high concentrations.

UI	MeSH Term	Description	Entries
D008564	Membrane Potentials	The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).	Resting Potentials,Transmembrane Potentials,Delta Psi,Resting Membrane Potential,Transmembrane Electrical Potential Difference,Transmembrane Potential Difference,Difference, Transmembrane Potential,Differences, Transmembrane Potential,Membrane Potential,Membrane Potential, Resting,Membrane Potentials, Resting,Potential Difference, Transmembrane,Potential Differences, Transmembrane,Potential, Membrane,Potential, Resting,Potential, Transmembrane,Potentials, Membrane,Potentials, Resting,Potentials, Transmembrane,Resting Membrane Potentials,Resting Potential,Transmembrane Potential,Transmembrane Potential Differences
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012908	Snails	Marine, freshwater, or terrestrial mollusks of the class Gastropoda. Most have an enclosing spiral shell, and several genera harbor parasites pathogenic to man.	Snail
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D014443	Tyrosine	A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.	L-Tyrosine,Tyrosine, L-isomer,para-Tyrosine,L Tyrosine,Tyrosine, L isomer,para Tyrosine
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In