-transparent.png){kind=logo}
A heat-sensitive, trypsin-sensitive factor that promoted growth and spreading of cells in serum-free, hormone-supplemented medium was partially purified from human serum. The major portion of the proteins in these preparations migrated upon SDS-polyacrylamide gel electrophoresis with a mobility consistent with molecular weights between 60,000 and 90,000. The spreading activity, which we have termed serum spreading factor, stimulated growth and spreading of a wide variety of cell types. The serum spreading factor was similar to fibronectin in that it showed an affinity for the plastic cell culture substrate but was shown to be distinct from fibronectin by several criteria. This factor may prove useful in studies of cell attachment and spreading and in studies of the relationship of cell shape and cell proliferation.
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
July 1988,
Blood,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
January 1988,
Pancreas,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
January 1987,
Calcified tissue international,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
June 1986,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
January 1998,
Journal of clinical periodontology,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
April 1990,
Biology of reproduction,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
September 1986,
Cell structure and function,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
February 1984,
Cancer research,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
March 2023,
Biomaterials advances,
D Barnes, and
R Wolfe, and
G Serrero, and
D McClure, and
G Sato
April 1978,
Proceedings of the National Academy of Sciences of the United States of America,
