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9, 11-Epithio-11, 12-methano-thromboxane A2 (STA2), a stable analogue of thromboxane A2, caused a rapid rise in cytoplasmic free Ca2+ concentration ([Ca2+]i) in human platelets as measured with the fluorescent Ca2+ indicator quin2. Concomitantly, this compound induced phosphorylation of myosin light chain which is catalyzed by Ca2+, calmodulin-dependent protein kinase. These reactions were fast enough to trigger serotonin release. 13-Azaprostanoic acid, a receptor level antagonist of thromboxane A2 inhibited STA2-induced elevation of [Ca2+]i, phosphorylation of myosin light chain and serotonin release. These results provide evidence that STA2 interacts with a thromboxane A2 receptor which leads to elevation of [Ca2+]i.
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
March 1986,
Thrombosis research,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
June 1988,
Journal of biochemistry,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
July 1985,
The American journal of physiology,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
November 1985,
FEBS letters,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
April 1986,
Thrombosis research,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
March 1986,
Thrombosis research,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
September 1987,
Blood,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
December 1986,
European journal of pharmacology,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
January 1980,
British journal of pharmacology,
Y Kawahara, and
J Yamanishi, and
Y Furuta, and
K Kaibuchi, and
Y Takai, and
H Fukuzaki
April 1988,
The Biochemical journal,
