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Fluorimetric titrations of mammalian [Arg8] LH-RH, chicken [Gln8] LH-RH and an analogue [Lys8] LH-RH revealed pK values of 5.80, 6.22 and 6.01 for His2, and 9.65, 9.88 and 9.88 for Tyr5. The titration ranges for His2 were 1.72, 2.03 and 1.71 while the range for Tyr5 was rather similar (approximately 1.7) for all three peptides. Biological activity and receptor binding in the mammalian system for chicken LH-RH was 1% relative to mammalian LH-RH while [Lys8] LH-RH had a relative activity of approximately 10%. In contrast, mammalian and chicken LH-RH were equipotent in stimulating LH release from chicken pituitary cells. The results indicate differences in the receptors related to the conformations of LH-RH and position 8-substituted analogues.
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
March 1983,
Life sciences,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
February 1986,
Nihon Naibunpi Gakkai zasshi,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
January 1983,
Peptides,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
December 1986,
General and comparative endocrinology,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
July 1985,
General and comparative endocrinology,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
January 1974,
Poultry science,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
December 1979,
Acta endocrinologica,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
January 1976,
Horumon to rinsho. Clinical endocrinology,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
September 1973,
Horumon to rinsho. Clinical endocrinology,
R C de L Milton, and
J A King, and
M N Badminton, and
C J Tobler, and
G G Lindsey, and
M Fridkin, and
R P Millar
January 1976,
Current topics in molecular endocrinology,
