Biomaterial Database

Antitumor effect of neocarzinostatin entrapped in liposomes. 1980

S Shinozawa, and Y Araki, and T Oda

Antitumor effect against mouse Ehrlich ascites carcinoma was examined on Neocarzinostatin (NCS) entrapped in sonicated liposomes (neutral and negatively or positively charged forms) in comparison with free NCS. In the intraperitoneal inoculation-intraperitoneal medication system, NSC entrapped in negatively charged liposomes, which was most unstable in aqueous solution, showed statistically significant prolongation of survival days in mice compared to free NCS. In contrast, survival days of the animals given NCS entrapped in positively charged liposomes were shorter than those of the corresponding groups given free NCS. On the other hand in the intraperitoneal inoculation-intravenous medication system, survival days were not prolonged markedly by administration of free NCS, BUT WHEN NCS was entrapped in positively charged or neutral liposomes, prolongation of survival was apparent compared to the corresponding groups given free NCS. The most marked effect was seen when NCS was entrapped in positively charged liposomes, which show the best stability in aqueous solution.

UI	MeSH Term	Description	Entries
D008081	Liposomes	Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.	Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D008297	Male		Males
D009353	Zinostatin	An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.	Neocarzinostatin
D002286	Carcinoma, Ehrlich Tumor	A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	Ehrlich Ascites Tumor,Ascites Tumor, Ehrlich,Ehrlich Tumor Carcinoma,Tumor, Ehrlich Ascites
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000903	Antibiotics, Antineoplastic	Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.	Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D014677	Pharmaceutical Vehicles	A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)	Pharmaceutical Vehicle,Vehicle, Pharmaceutical,Vehicles, Pharmaceutical
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus