-transparent.png){kind=logo}
The biological degradation of tetraethyl lead to the triethyl lead cation by rat-liver microsomes from untreated, phenobarbital-pretreated and methylcholanthrene-pretreated rats has been studied; NADPH and oxygen are essential. The reaction is inhibited by CO and can be reactivated in the presence of O2 by irradiation with u.v. light with a max. at 450 nm. Substrate binding to cytochrome P-450 is of type 1. Apparent Km values for triethyl lead formation in microsomes were determined. The highest activities (i.e. about 2 nmol triethyl lead per nmol cytochrome P-450 per min) and the lowest apparent Km values (i.e. 7 X 10(-6) M) are found in microsomes from methylcholanthrene-pretreated rats. In microsomes from control and phenobarbital-pretreated rats Ks values from substrate-binding studies (about 2 X 10(-6) M) are one order of magnitude lower than the apparent Km values (3 X 10(-5) M).
D Ferreira da Silva, and
U Schröder, and
H Diehl
October 1985,
Xenobiotica; the fate of foreign compounds in biological systems,
D Ferreira da Silva, and
U Schröder, and
H Diehl
October 1983,
Xenobiotica; the fate of foreign compounds in biological systems,
D Ferreira da Silva, and
U Schröder, and
H Diehl
August 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
D Ferreira da Silva, and
U Schröder, and
H Diehl
July 1985,
Xenobiotica; the fate of foreign compounds in biological systems,
D Ferreira da Silva, and
U Schröder, and
H Diehl
December 1958,
The Biochemical journal,
D Ferreira da Silva, and
U Schröder, and
H Diehl
September 1998,
The Journal of pharmacy and pharmacology,
D Ferreira da Silva, and
U Schröder, and
H Diehl
January 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
D Ferreira da Silva, and
U Schröder, and
H Diehl
October 1990,
Biokhimiia (Moscow, Russia),
D Ferreira da Silva, and
U Schröder, and
H Diehl
August 1970,
Biochemical pharmacology,
D Ferreira da Silva, and
U Schröder, and
H Diehl
January 1967,
Polskie Archiwum Medycyny Wewnetrznej,
