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The cellular abundance of H2A, H2B, H3 and H4 histone mRNA sequences was determined prior to and at various times after stimulation of non-dividing human diploid fibroblasts to proliferate. The representation of histone mRNAs was quantitated by electrophoretic fractionation of total cellular RNAs, diffusion transfer to nitrocellulose and hybridization with a series of cloned genomic human histone sequences. The levels of mRNAs for the four core histones were observed to be temporally and quantitatively coupled with both DNA replication and histone protein synthesis. Therefore, a contribution to the regulation of histone gene expression at a transcriptional level is suggested.
L Green, and
G Stein, and
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February 1982,
Proceedings of the National Academy of Sciences of the United States of America,
L Green, and
G Stein, and
J Stein
August 2010,
BMC molecular biology,
L Green, and
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J Stein
September 1995,
Oncogene,
L Green, and
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J Stein
January 1996,
Experimental gerontology,
L Green, and
G Stein, and
J Stein
November 1983,
Nucleic acids research,
L Green, and
G Stein, and
J Stein
October 1984,
Mechanisms of ageing and development,
L Green, and
G Stein, and
J Stein
October 1992,
Proceedings of the National Academy of Sciences of the United States of America,
L Green, and
G Stein, and
J Stein
April 1983,
Biochimica et biophysica acta,
L Green, and
G Stein, and
J Stein
January 1977,
Proceedings of the National Academy of Sciences of the United States of America,
L Green, and
G Stein, and
J Stein
October 1989,
Experimental cell research,
