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We have utilized sodium butyrate-treated normal human diploid fibroblasts to study core histone hyperacetylation kinetics. We report a small, distinct population of core histone characterized by a very rapid rate of hyperacetylation (t1/2 approximately equal to 10-15 min for monoacetylated histone H4) compared to the slower rate (t1/2 approximately equal to 140-200 min for monoacetylated H4) observed for bulk histone. Two rates of core histone deacetylation were also detected and we demonstrated that the rapidly hypermodified histone H4 population was also rapidly deacetylated. The kinetics of histone H4 hyperacetylation and deacetylation in these cells were not significantly altered, regardless of whether cultures were exponentially growing, confluent or arrested in an essentially non-mitotic state.
M R Duncan, and
M J Robinson, and
R T Dell'Orco
May 1988,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
January 1984,
Molecular and cellular biochemistry,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
January 1981,
Journal of cellular physiology,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
June 2001,
The Journal of biological chemistry,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
February 1982,
Journal of cellular physiology,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
April 2024,
Genes,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
June 2015,
Biotechnology letters,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
January 2002,
Molecular biotechnology,
M R Duncan, and
M J Robinson, and
R T Dell'Orco
November 1983,
Biokhimiia (Moscow, Russia),
M R Duncan, and
M J Robinson, and
R T Dell'Orco
January 1977,
Proceedings of the National Academy of Sciences of the United States of America,
