-transparent.png){kind=logo}
High density lipoprotein cholesterol (HDL-chol) is negatively associated with coronary heart disease. Environmental heart disease risk factors may partially be related to coronary heart disease through alterations in HDL-chol concentrations. Little is known about the underlying mechanisms by which environmental factors are related to HDL-chol. The authors investigated a possible mechanism: changes in liver function as a mediating link between risk factors and HDL-chol concentrations in marathon runners, alcoholics, and participants in the Multiple Risk Factor Intervention Trial. Liver function, as measured by liver enzymes, was related to both coronary heart disease risk factors and alcohol consumption, suggesting that the increased levels of HDL-chol associated with alcohol were primarily the result of changes in liver function. The relationship of obesity to HDL-chol could not be explained by the alterations in liver function.
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
January 1983,
Hepatology (Baltimore, Md.),
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
October 1983,
Atherosclerosis,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
June 2008,
Journal of the American College of Cardiology,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
July 2004,
Current opinion in cardiology,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
February 1987,
American heart journal,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
June 1997,
Current opinion in lipidology,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
January 1980,
JAMA,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
December 1981,
The New England journal of medicine,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
April 1982,
JAMA,
L H Kuller, and
S B Hulley, and
R E LaPorte, and
J Neaton, and
W S Dai
January 1989,
Arteriosclerosis (Dallas, Tex.),
