BIOMAT Database Logo BIOMAT Database Logo

[Action of the antitumor antibiotics, rubomycin and carminomycin, on the T- and B-cell population ratio in mouse lymphoid organs]. 1980

A E Vatin

Quantitative ratios of T- and B-cells in the lymphoid organs of mice were studied comparatively at various periods after administration of rubomycin and carminomycin in maximum tolerated doses, i. e. 20 and 3 mg/kg. It was found that the antibiotics decreased the total number of the cariocytes in these organs and induced irregular elimination of T- and B-cells from the spleen and lymph nodes. Comparison of the time-course of T- and B-lymphocyte population reduction suggested that the cells reduced independently of each other, the reduction rate of B-cells being higher than that of T-cells.

UI MeSH Term Description Entries
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008221 Lymphoid Tissue Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS. Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D008297 Male Males
D008808 Mice, Inbred CBA An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH. Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D002360 Carubicin A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata. Carminomycin,Karminomycin,Carminomicin,Carminomycin I,Carminomycin II,Carminomycin III,Carubicin Hydrochloride,Demethyldaunomycin,Demethyldaunorubicin,Karminomicin,NSC-180,024,NSC-180024,Rubeomycin A,Rubeomycin A1,Hydrochloride, Carubicin,NSC 180,024,NSC 180024,NSC180,024,NSC180024
D003630 Daunorubicin A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. Daunomycin,Rubidomycin,Rubomycin,Cerubidine,Dauno-Rubidomycine,Daunoblastin,Daunoblastine,Daunorubicin Hydrochloride,NSC-82151,Dauno Rubidomycine,Hydrochloride, Daunorubicin,NSC 82151,NSC82151
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte

Related Publications

A E Vatin
[Comparative cytogenetic action of the antitumor antibiotics, carminomycin and rubomycin].
June 1978, Antibiotiki,
A E Vatin
[Morphological changes in the digestive organs on the administration of the antineoplastic antibiotics, rubomycin and carminomycin].
February 1978, Antibiotiki,
A E Vatin
[Immunodepressive action of carminomycin and rubomycin derivatives].
July 1979, Antibiotiki,
A E Vatin
[Quantitative interrelationships between the T- and B-cell populations of mouse lymphoid organs].
July 1978, Tsitologiia,
A E Vatin
[Comparative pathomorphological study of the experimental action of carminomycin and rubomycin on the heart].
October 1978, Antibiotiki,
A E Vatin
[Effect of microbial and tumor cell adaptation to rubomycin on their uptake of rubomycin and carminomycin].
September 1978, Antibiotiki,
A E Vatin
[New derivatives of carminomycin and rubomycin].
October 1988, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
A E Vatin
[Comparative study of the cardiotoxicity of the anthracycline antibiotics, rubomycin, carminomycin and dihydrocarminomycin, in experiments on white mice].
January 1978, Antibiotiki,
A E Vatin
[Comparative evaluation of the cytogenetic action of anthracycline-group antitumor antibiotics (daunomycin, doxorubicin and carminomycin)].
October 1986, Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology,
A E Vatin
[Comparison of carminomycin and rubomycin action on the dynamics of the immune response to the T-independent Vi-antigen of S. typhi].
February 1980, Antibiotiki,
Copied contents to your clipboard!