Biomaterial Database

Dominant lethal mutation induced in male rats by 1,2-dibromo-3-chloropropane (DBCP). 1980

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

1,2-Dibromoethane (DBE) and 1,2-dibromo-3-chloropropane (DBCP), soil fumigants, were investigated for their potential mutagenicity by dominant lethal studies in the rat and mouse. Dominant lethal mutation was induced by DBE in neither of the species. DBCP, on the other hand, induced dominant lethals in rats in the post-meiotic stage of spermatogenesis, especially in the early spermatid stage. However, DBCP did not cause dominant lethals in mice.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009153	Mutagens	Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.	Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D011407	Propane	A three carbon alkane with the formula H3CCH2CH3.
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005799	Genes, Dominant	Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.	Conditions, Dominant Genetic,Dominant Genetic Conditions,Genetic Conditions, Dominant,Condition, Dominant Genetic,Dominant Gene,Dominant Genes,Dominant Genetic Condition,Gene, Dominant,Genetic Condition, Dominant
D005804	Genes, Lethal	Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.	Alleles, Lethal,Allele, Lethal,Gene, Lethal,Lethal Allele,Lethal Alleles,Lethal Gene,Lethal Genes
D005821	Genetic Techniques	Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.	Genetic Technic,Genetic Technics,Genetic Technique,Technic, Genetic,Technics, Genetic,Technique, Genetic,Techniques, Genetic
D006846	Hydrocarbons, Halogenated	Hydrocarbon compounds with one or more HYDROGEN atoms substituted with HALOGENS.	Halogenated Hydrocarbons
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species

Related Publications

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Tests for dominant-lethal effects of 1,2-dibromo-3-chloropropane (DBCP) in male and female mice.

January 1985, Mutation research,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

1,2-dibromo-3-chloropropane (DBCP)-induced infertility in male rats mediated by a post-testicular effect.

November 1983, Toxicology and applied pharmacology,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Radiomimetic toxicity of 1,2-dibromo-3-chloropropane (DBCP).

January 1986, Industrial health,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Genetic toxicology of 1,2-dibromo-3-chloropropane (DBCP).

July 1989, Mutation research,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Toxicity of 1,2-dibromo-3-chloropropane (DBCP). I. Histopathological examination of male rats exposed to DBCP vapour.

January 1982, Industrial health,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

1,2-Dibromo-3-chloropropane (DBCP)-induced nuclear atypia in rat kidney.

January 1989, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Volatilization of 1,2-dibromo-3-chloropropane (DBCP) from soils.

January 1979, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Toxicokinetics of 1,2-dibromo-3-chloropropane (DBCP) in the rat.

December 1987, Toxicology and applied pharmacology,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Genetic effects of 1,2-dibromo-3-chloropropane (DBCP) in Drosophila.

January 1982, Environmental mutagenesis,

S Teramoto, and R Saito, and H Aoyama, and Y Shirasu

Prevention of 1,2-dibromo-3-chloropropane (DBCP)-induced kidney necrosis and testicular atrophy by 3-aminobenzamide.

August 1991, Toxicology and applied pharmacology,