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DBCP was studied for dominant-lethal effects in male and female mice and for total reproductive effects in females. In males it was administered either intraperitoneally or subcutaneously while in females it was given only by the former route. No DBCP-related response was observed in either males or females indicating its ineffectiveness in inducing chromosomal aberrations or cytotoxicity in mouse germ cells. These findings differ markedly from the observations made in rats by other investigators. Thus, the probable existence of a species difference in germ cell response to DBCP has been strengthened by the availability of the present results. It should be noted, however, that only two stocks of male mice have been studied so far for dominant-lethal and germ cell cytotoxicity effects.
W M Generoso, and
K T Cain, and
L A Hughes
January 1980,
Mutation research,
W M Generoso, and
K T Cain, and
L A Hughes
January 1982,
Environmental mutagenesis,
W M Generoso, and
K T Cain, and
L A Hughes
January 1986,
Industrial health,
W M Generoso, and
K T Cain, and
L A Hughes
July 1989,
Mutation research,
W M Generoso, and
K T Cain, and
L A Hughes
January 1979,
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes,
W M Generoso, and
K T Cain, and
L A Hughes
January 1989,
Industrial health,
W M Generoso, and
K T Cain, and
L A Hughes
December 1987,
Toxicology and applied pharmacology,
W M Generoso, and
K T Cain, and
L A Hughes
January 1982,
Industrial health,
W M Generoso, and
K T Cain, and
L A Hughes
January 1989,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
W M Generoso, and
K T Cain, and
L A Hughes
January 1999,
International journal of occupational and environmental health,
