Biomaterial Database

Chicken intrapulmonary chemoreceptors: discharge at static levels of intrapulmonary carbon dioxide and their location. 1978

P C Nye, and R E Burger

We studied 54 intrapulmonary chemoreceptors in the unidirectionally ventilated left lungs of 12 thoracotomized cockerels. We ligated the left pulmonary artery to eliminate CO2 contributed by mixed venous blood. At zero PCO2 many units discharge irregularly, and some cease discharging after several seconds. Discharge frequencies at 13.7 torr PCO2 and above are described by logarithmic regressions. The slopes and intercepts of the logarithmic regressions are correlated so that the average response can be written: frequency = 3.86 -B . 1n (24.5 PCO2-1). Afferent activity above 6.8 torr PCO2 is described by 0.073 + 78.6 exp (-0.11 PCO2) -63.3 exp (-0.15 PCO2). For each unit, receptive site PCO2 in a perfused lung was assumed to be the PCO2 in the unperfused lung which gave the same discharge frequency. Location of the receptor was determined as the fraction of ventilation-perfusion region which had the same PCO2 as receptive site PCO2. Two major concentrations of receptors accounted for 85% of the total, one near the entering gas and one near the middle of the gas-exchange region. Sensitivity of individual receptors did not vary systematically with location.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011651	Pulmonary Artery	The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.	Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D002628	Chemoreceptor Cells	Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.	Chemoreceptive Cells,Cell, Chemoreceptive,Cell, Chemoreceptor,Cells, Chemoreceptive,Cells, Chemoreceptor,Chemoreceptive Cell,Chemoreceptor Cell
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000344	Afferent Pathways	Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.	Afferent Pathway,Pathway, Afferent,Pathways, Afferent
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014630	Vagus Nerve	The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).	Cranial Nerve X,Pneumogastric Nerve,Tenth Cranial Nerve,Nerve X,Nervus Vagus,Cranial Nerve, Tenth,Cranial Nerves, Tenth,Nerve X, Cranial,Nerve Xs,Nerve, Pneumogastric,Nerve, Tenth Cranial,Nerve, Vagus,Nerves, Pneumogastric,Nerves, Tenth Cranial,Nerves, Vagus,Pneumogastric Nerves,Tenth Cranial Nerves,Vagus Nerves,Vagus, Nervus
D014692	Ventilation-Perfusion Ratio	The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)	Ratio, Ventilation-Perfusion,Ratios, Ventilation-Perfusion,Ventilation Perfusion Ratio,Ventilation-Perfusion Ratios