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The formation and clearance of circulating IgA immune complexes from blood to bile was investigated in this study. The i.v. injection of either MOPC-315, an IgA M-component with antidinitrophenyl (DNP) specificity, or TEPC-15, an IgA M-component of a different specificity, was followed by i.v. injection of 125I-DNP10-bovine serum albumin (BSA) as the antigen. The formation and clearance of IgA immune complexes in the circulation of MOPC-315-treated, but not TEPC-15-treated animals was demonstrated by immunoprecipitation with polyacrylamide beads coated with rabbit anti-mouse IgA. IgA-125I-DNP10-BSA complexes were identified in the bile from MOPC-315-treated, but not TEPC-15-treated animals utilizing this same immunoprecipitation technique. These observations suggest that the liver or bile ducts transport IgA immune complexes from blood into bile. The clearance of 125I-DNP10-BSA from the circulation was documented by coprecipitation with rabbit anti-BSA and BSA. The clearance of this circulating antigen was slower in the MOPC-315-treated than in the TEPC-15-treated animals suggesting that under the conditions of the present experiment, circulating antigen is cleared more slowly after IgA immune complex formation.
P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
November 2018,
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P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
May 1982,
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P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
October 1989,
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P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
April 1980,
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P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
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P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
October 1983,
Clinical and experimental immunology,
P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
September 1979,
Clinical and experimental immunology,
P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
September 1985,
European journal of immunology,
P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
February 1991,
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P R Harmatz, and
R E Kleinman, and
B W Bunnell, and
K J Bloch, and
W A Walker
April 1983,
Journal of immunology (Baltimore, Md. : 1950),
