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The induction of 6-thioguanine-resistant (TGr) mutants and sister-chromatid exchanges (SCE) by 5-bromo- and 5-chloro-deoxyuridine (BrdU and CldU) was determined with Chinese hamster ovary cells in culture. Over a concentration range of 0.5-200 microM, CldU treatment caused 3-5 times the number of SCEs found with BrdU; for example, with 10 microM CldU, 60.0 +/- 14.2 SCEs/metaphase (mean +/- S.D.) were induced, while with 10 microM BrdU, only 14.6 +/- 4.1 SCEs/metaphase were found. Despite this difference in SCE induction, both compounds were mutagenic only at concentrations greater than 50 microM, and BrdU was more mutagenic than CldU. These results indicate that SCEs and gene mutations are induced by these thymidine analogs through 2 different mechanisms.
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
November 1989,
Somatic cell and molecular genetics,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
January 1980,
Cytogenetics and cell genetics,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
February 1987,
Genome,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
August 1984,
Mutation research,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
January 1987,
Mutation research,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
September 1985,
Mutation research,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
January 1982,
Chromosoma,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
January 1980,
Environmental mutagenesis,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
November 1979,
Mutation research,
M W Heartlein, and
J P O'Neill, and
B C Pal, and
R J Preston
December 1986,
Cell biology and toxicology,
