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Inhibitory effects of quassinoids on Epstein-Barr virus activation. 1995
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.
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