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Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of naphthoquinones. 2003
Junko Koyama, and
Izumi Morita, and
Norihiro Kobayashi, and
Toshiyuki Osakai, and
Hiroki Hotta, and
Junko Takayasu, and
Hoyoku Nishino, and
Harukuni Tokuda
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658, Japan. j-koyama@kobepharma-u.ac.jp
As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some naphthoquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the naphthoquinones on Epstein-Barr virus early antigen activation. It has been further shown that the correlation can be enhanced by introducing an electronic property, i.e. the atomic charges at the C(4) and O(10) atoms in the quinone skeleton ring as additional parameters.
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