-transparent.png){kind=logo}
To search for possible antitumor promoters, we carried out a primary screening of thirty-seven dihydroagarofuran sesquiterpenes from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, using their possible inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these sesquiterpenes, triptofordin F-2 (Takaishi et al., 1988), 1,2,6,8,15-pentaacetoxy-9-benzoyloxy-4-hydroxy-beta-dihydroagarofuran and triptogelin A-1 (Takaishi et al., 1990) were observed to significantly inhibit the EBV-EA activation at low doses. Based on the results, the structural requirements for the activity of these compounds were discussed [corrected].
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
August 1995,
Cancer letters,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
February 2003,
Bioorganic & medicinal chemistry,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
September 2001,
Cancer letters,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
April 1997,
Chemical & pharmaceutical bulletin,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
December 1995,
Planta medica,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
December 2003,
Chemical & pharmaceutical bulletin,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
August 2003,
Journal of natural products,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
May 1997,
Cancer letters,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
August 1995,
Planta medica,
Y Takaishi, and
K Ujita, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
November 2003,
Cancer letters,
