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Gel filtration chromatography in Sephadex G-100, was used to analyse the molecular heterogeneity of prolactin (PRL) in serum from seven hyperprolactinemic women. Chromatographic patterns from samples obtained from four women with hyperprolactinemia and normal menstrual cycles showed a predominance of big-big PRL (79%). In contrast, three women with hyperprolactinemia and amenorrhea presented a chromatographic pattern with predominance of little PRL (69%). The results suggest that the molecular heterogeneity of PRL found is associated with menstrual cycles disorders and hence with ovarian function. Normal ovarian function in hyperprolactinemic patients seems to be associated to increased levels of big-big PRL and altered ovarian function to high level of little PRL.
C Romero, and
J León, and
R Jara, and
O González
May 2000,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
C Romero, and
J León, and
R Jara, and
O González
January 1995,
Journal of basic and clinical physiology and pharmacology,
C Romero, and
J León, and
R Jara, and
O González
November 1977,
The Journal of clinical endocrinology and metabolism,
C Romero, and
J León, and
R Jara, and
O González
November 1977,
The Journal of clinical endocrinology and metabolism,
C Romero, and
J León, and
R Jara, and
O González
January 1978,
Journal of endocrinological investigation,
C Romero, and
J León, and
R Jara, and
O González
January 1985,
Gynecologic and obstetric investigation,
C Romero, and
J León, and
R Jara, and
O González
March 1994,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C Romero, and
J León, and
R Jara, and
O González
January 1989,
The Journal of clinical endocrinology and metabolism,
C Romero, and
J León, and
R Jara, and
O González
May 1989,
The Journal of clinical endocrinology and metabolism,
C Romero, and
J León, and
R Jara, and
O González
October 1987,
Endocrinologia japonica,
