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The two major isoforms of 2',3'-cyclic nucleotide phosphodiesterase (CNP), 48 and 46 kDa, have recently been shown to be produced from a single gene by alternative splicing. In addition, messenger RNA encoding the larger isoform is transcribed from a separate promoter, approximately 1 kb upstream from that encoding the smaller isoform. We have investigated the expression of these two CNP isoforms and have found that they are differentially expressed during the process of oligodendrocyte maturation. In oligodendrocyte precursors, only the mRNA encoding the larger protein is found. At the time of oligodendrocyte differentiation, however, both CNP mRNAs are induced. These patterns of CNP expression are likely due to stage-specific transcriptional regulation of the two CNP promoters during the process of oligodendrocyte differentiation.
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
December 1989,
Biochemical and biophysical research communications,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
September 1992,
Brain research. Molecular brain research,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
June 1996,
Molecular and cellular neurosciences,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
November 2000,
Journal of neurochemistry,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
January 1992,
Journal of cellular physiology,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
February 2008,
Psychiatry and clinical neurosciences,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
January 1989,
Critical reviews in neurobiology,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
February 1981,
Journal of neurochemistry,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
March 1996,
Nucleic acids research,
S S Scherer, and
P E Braun, and
J Grinspan, and
E Collarini, and
D Y Wang, and
J Kamholz
July 1992,
Annals of human genetics,
