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We have constructed a high-resolution cytogenetic map of human chromosome 12 with 195 newly isolated cosmids by direct R-banding fluorescence in situ hybridization. The fluorescent signals of 195 clones were evenly distributed throughout chromosome 12, but sublocalized preferentially to R-positive bands. This high-resolution cytogenetic map with an average map distance of 0.73 Mb on bands can, in conjunction with a genetic linkage map, facilitate the analysis of chromosomal and molecular aberrations in genetic diseases and cancers. Moreover, the cytogenetic mapping data provide starting points for establishing contig maps with cosmid clones and yeast artificial chromosomes.
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
July 1993,
Genomics,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
August 1992,
Genomics,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
July 1993,
Genomics,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
May 1992,
Genomics,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
February 1993,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
November 1992,
Japanese journal of cancer research : Gann,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
January 1995,
Cytogenetics and cell genetics,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
January 1990,
Science (New York, N.Y.),
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
January 1999,
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
E Takahashi, and
K Koyama, and
A Hitomi, and
Y Nakamura
January 2003,
Cytogenetic and genome research,
