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Inhibitory effects of 3-nitrophloroglucinecarboxylic acid derivatives on Epstein-Barr virus early antigen induction. 1993
I Honda, and
H Tokuda, and
M Kozuka, and
K Yoneyama, and
H Nishino, and
A Iwashima, and
M Shibagaki, and
M Noma, and
N Takahashi, and
S Yoshida
Life Science Research Laboratory, Japan Tobacco Inc., Yokohama.
The inhibitory effects of two series of 3-nitrophloroglucinecarboxylic acid derivatives, 3-nitro-2,4,6-trihydroxythiobenzamides (II) and 3-nitro-phloroglucinecarboxylates (III), on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of them strongly inhibited the induction, N-nonyl and O-decyl derivatives being the most potent inhibitors among the thioamides and esters, respectively. These results suggest the possibility that these two 3-nitrophloroglucinecarboxylic acid derivatives may be listed as novel inhibitors of tumor promotion.
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