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Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation. 1997
S Rahman, and
N Fukamiya, and
N Ohno, and
H Tokuda, and
H Nishino, and
K Tagahara, and
K H Lee, and
M Okano
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.
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