Biomaterial Database

Effect of renal fuels on p-aminohippurate transport in rat renal cortical fragments. 1977

A S Kliger, and S T Eastman, and M Zachek, and M Kullick, and H G Preuss

The effects of the major renal fuels were studied, i.e., lactate, citrate, palmitate, glutamine, and glucose, at concentrations near those found circulating on the in vitro accumulation of p-aminohippurate (PAH) by rat renal cortical fragments. Only lactate and citrate were found to increase PAH uptake significantly. Noting that 10% v/v normal rat sera enhance PAH accumulation, we studied the renal fuels at 10% circulating concentrations and found that all fuels combined had stimulation comparable to 10% v/v sera. Lactate and the stimulator in normal sera are located in the same Sephadex G-25 fraction of sera. Both lactate, the major renal fuel, and normal sera stimulate the influx and inhibit the efflux of PAH. We conclude that the stimulators to PAH transport in normal sera are, at least in part, renal fuel organic anions.

UI	MeSH Term	Description	Entries
D007672	Kidney Cortex	The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.	Cortex, Kidney
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D007773	Lactates	Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008297	Male		Males
D010130	p-Aminohippuric Acid	The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.	4-Aminohippuric Acid,para-Aminohippuric Acid,Aminohippurate Sodium,Aminohippuric Acid,Nephrotest,Sodium Para-Aminohippurate,p-Aminohippurate,4 Aminohippuric Acid,Para-Aminohippurate, Sodium,Sodium Para Aminohippurate,Sodium, Aminohippurate,p Aminohippurate,p Aminohippuric Acid,para Aminohippuric Acid
D010168	Palmitates	Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid.	Hexadecanoates,Palmitate
D011773	Pyruvates	Derivatives of PYRUVIC ACID, including its salts and esters.
D001769	Blood	The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
D002951	Citrates	Derivatives of CITRIC ACID.
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose