Biomaterial Database

The levels of cadmium, zinc and copper in the renal cortex and liver of the inhabitants of the copper basin. 1996

C Orłowski, and J K Piotrowski, and M Kubów

Department of Toxicological Chemistry Medical University, Lodz, Poland.

Tissues were analysed from 60 subjects deceased at the age of 18-82 (mean 49 years), inhabitants of the southwestern region of Poland (Legnica Copper Basin). Mean cadmium, zinc and copper concentrations determined by flame AAS were for renal cortex 41.8; 47.8 and 2.3 micrograms Me/g tissue, respectively. The respective levels in the liver were 2.3; 51.6 and 4.6 micrograms Me/g tissue (w.w.). A broad range of cadmium levels was found in renal cortex (4.2-129.3.micrograms/g), with the highest values in the 40-60 age group. The effect of tobacco smoking is more evident than in other countries: 26.3 micrograms/g in non-smokers vs. 54.6 micrograms/g in smokers. Similar proportions were found by computing the whole body burden of cadmium. Compared with other regions of Poland the environmental exposure of humans to cadmium is moderate, however, it is higher than in other European countries.

UI	MeSH Term	Description	Entries
D007672	Kidney Cortex	The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.	Cortex, Kidney
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011044	Poland	A country in central Europe, east of Germany. The capital is Warsaw.	Polish People's Republic,Republic of Poland
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002104	Cadmium	An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D004781	Environmental Exposure	The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.	Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D005060	Europe	The continent north of AFRICA, west of ASIA and east of the ATLANTIC OCEAN.	Northern Europe,Southern Europe,Western Europe