BIOMAT Database Logo BIOMAT Database Logo

Isolation of a marker for head-specific cell differentiation in hydra. 1996

I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Zentrum für Molekulare Neurobiologie, Universität Hamburg, Germany.

A cDNA was isolated from Hydra vulgaris coding for a 360 amino acid long polypeptide with no significant similarity to any known protein. In situ hybridization showed that the corresponding transcript is expressed exclusively in endodermal cells of the hypostome, hence its name hyp 1. Hyp 1 therefore represents a highly specific marker for the head region of hydra. In accordance with this, we found that hyp 1 expression was strong in tissues regenerating a head. Hyp 1 reappeared early during head regeneration, namely 6-8 h after initiation of regeneration by cutting. These findings imply that hyp 1 is an excellent marker for monitoring early events in head-specific differentiation processes in hydra.

UI MeSH Term Description Entries
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D012038 Regeneration The physiological renewal, repair, or replacement of tissue. Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D003001 Cloning, Molecular The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells. Molecular Cloning
D005819 Genetic Markers A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event. Chromosome Markers,DNA Markers,Markers, DNA,Markers, Genetic,Genetic Marker,Marker, Genetic,Chromosome Marker,DNA Marker,Marker, Chromosome,Marker, DNA,Markers, Chromosome
D006257 Head The upper part of the human body, or the front or upper part of the body of an animal, typically separated from the rest of the body by a neck, and containing the brain, mouth, and sense organs. Heads
D006829 Hydra A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals. Hydras
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein

Related Publications

I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
prdl-a, a gene marker for hydra apical differentiation related to triploblastic paired-like head-specific genes.
May 1998, Development (Cambridge, England),
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Selective protein kinase inhibitors block head-specific differentiation in hydra.
October 2000, Cellular signalling,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Effect of head activator on proliferation, head-specific determination and differentiation of epithelial cells in hydra.
June 1990, Differentiation; research in biological diversity,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Regulation of interstitial cell differentiation in Hydra attenuata. V. Inability of regenerating head to support nematocyte differentiation.
December 1978, Journal of cell science,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Stimulation of head-specific nerve cell formation in Hydra by pulses of diacylglycerol.
October 1991, Developmental biology,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Regulation of interstitial cell differentiation in Hydra attenuata. IV. Nerve cell commitment in head regeneration is position-dependent.
December 1978, Journal of cell science,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors.
May 2018, The American journal of surgical pathology,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Ks1, an epithelial cell-specific gene, responds to early signals of head formation in Hydra.
September 1994, Development (Cambridge, England),
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
A role of inductive factors in interstitial cell differentiation in Hydra.
April 1970, The Journal of experimental zoology,
I Hermans-Borgmeyer, and B Schinke, and H C Schaller, and S A Hoffmeister-Ullerich
Rapid isolation of monoclonal antibodies specific for cell surface differentiation antigens.
June 1986, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!