Letter: 5-iodoacetamidomethyl-2'-deoxyuridine 5'-phosphate. A selective inhibitor of mammalian thymidylate synthetases.
1976
R L Barfknecht, and
R A Huet-Rose, and
A Kampf, and
M P Mertes
UI
MeSH Term
Description
Entries
D007460
Iodoacetamide
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
D008780
Methyltransferases
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
Methyltransferase
D013940
Thymidylate Synthase
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.