-transparent.png){kind=logo}
Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues. 1998
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago, Spain.
(1R,cis)-2-(3-Amino-2,2-dimethylcyclobutyl)ethanol (4) was used as a precursor in the synthesis of cyclobutyl nucleoside analogues containing guanine, 8-azaguanine, adenine or 8-azaadenine. All the compounds were evaluated as antiviral agents in a variety of assay systems. Some activity was noted for compound 13, 17, 19 and 20 against vaccinia virus and for compounds 11, 12, 13, 17, 19 and 20 against herpes simplex virus, at concentrations that were up to 10-fold below the cytotoxic concentrations for the host cells.
Related Publications
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
September 2001,
Chemical & pharmaceutical bulletin,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
August 1997,
Archiv der Pharmazie,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
October 1999,
Archiv der Pharmazie,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
October 1999,
Nucleosides & nucleotides,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
January 2002,
Nucleosides, nucleotides & nucleic acids,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
July 1998,
Nucleosides & nucleotides,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
September 1986,
Journal of medicinal chemistry,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
September 1981,
Journal of medicinal chemistry,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
July 1995,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
J E Borges, and
F Fernández, and
X García, and
A R Hergueta, and
C López, and
G Andrei, and
R Snoeck, and
M Witvrounw, and
J Balzarini, and
E De Clercq
January 1999,
Nucleic acids symposium series,
