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Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues. 1998
M I Nieto, and
J M Blanco, and
O Caamaño, and
F Fernández, and
X García-Mera, and
J Balzarini, and
E Padalko, and
J Neyts, and
E De Clercq
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago, Spain.
Six new carbocyclic nucleosides were prepared by mounting a purine (compounds 5-7), 8-azapurine (compounds 9 and 10) or pyrimidine (compound 13) base on the amino group of (1R,cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2). The antiviral activity of compounds 5-7, 10 and 13, and their cytostatic activity, were evaluated. At subtoxic concentrations, the compounds showed no or marginal antiviral activity. Compound 5 showed moderate inhibition on tumor cell proliferation.
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