Statistical correlation between transient pressure drop and cavitation at closure of a mechanical heart valve. 2005

Changfu Wu, and Jia-Shing Liu, and Ned H C Hwang, and Yu-Kweng M Lin
Center for Applied Stochastics Research, College of Engineering, Florida Atlantic University, 777 Glades Rd., Boca Raton, FL 33431, USA.

Cavitation on a mechanical heart valve (MHV) is attributable to transient regional pressure drop at the instant of valve closure. As a cavitation bubble collapses, it emits shock waves, which have the characteristics of high frequency oscillations (HFO) on a pressure time trace. The potential for such HFO bursts to cause material damage on an MHV can be measured by the cavitation impulse I, which is defined as the area under the trace of the HFO bursts. In the present study, experiments were conducted on a bileaflet MHV in a durability tester, operated at pulse rates from 300-1,000 bpm. In each case, the transient pressure near an occluder was monitored for 60,000 beats via a transducer. The peak pressure drop Pm and the corresponding cavitation impulse I obtained for the 60,000 beat sequence are found to resemble sample records of two stationary stochastic processes, each of which follows a log normal distribution. Their first order probability density functions are estimated from the records. The correlation is investigated between I and Pm associated with each beat, which is found to be of statistical significance.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D011312 Pressure A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Pressures
D011338 Probability Theory The branch of mathematics dealing with the purely logical properties of probability. Its theorems underlie most statistical methods. (Last, A Dictionary of Epidemiology, 2d ed) Probability Theories,Theories, Probability,Theory, Probability
D011474 Prosthesis Design The plan and delineation of prostheses in general or a specific prosthesis. Design, Prosthesis,Designs, Prosthesis,Prosthesis Designs
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006350 Heart Valve Prosthesis A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material. Prosthesis, Heart Valve,Cardiac Valve Prosthesis,Cardiac Valve Prostheses,Heart Valve Prostheses,Prostheses, Cardiac Valve,Prostheses, Heart Valve,Prosthesis, Cardiac Valve,Valve Prostheses, Cardiac,Valve Prostheses, Heart,Valve Prosthesis, Cardiac,Valve Prosthesis, Heart
D001698 Biomedical Engineering Application of principles and practices of engineering science to biomedical research and health care. Clinical Engineering,Engineering, Clinical,Engineering, Biomedical
D013995 Time The dimension of the physical universe which, at a given place, orders the sequence of events. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Effects, Long-Term,Effects, Longterm,Long-Term Effects,Longterm Effects,Effect, Long-Term,Effect, Longterm,Effects, Long Term,Long Term Effects,Long-Term Effect,Longterm Effect
D014159 Transducers Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed) Transducer

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